Nanosphere is a privately held company founded in 2000 in Northbrook, IL with an aim to use nanoscale particles to improve systems for biological testing. Nanosphere's product, Verigene TM, uses patented gold nanoprobes to detect proteins and nucleic acids for applications ranging from scientific research to security detection. Nanosphere has received over $80M in four rounds of financing, principally from Lurie Investments and Bain Capitall, in addition to a $1.5M grant from the NIH. Nanosphere is an exciting nanocompany in a high growth biosensors market currently estimated at $2B, and was named in 2002 to Red Herring magazine's 100 list of exciting new high-technology companies. Nanosphere has patented over 43 technologies and, though the company is still in its early stages, sales are estimated by Hoovers.com at around $3.5M thus far.
Nanosphere-inc.com
Technology
Nanosphere takes advantage of unique properties of gold nanoparticles (see TECHNOLOGY:Nanoshells) to probe for DNA, RNA, and proteins. The nanoprobes are coated with complementary sequences to the protein or nucleic acid under scrutiny which can, upon recognition, catalyze a reaction on the nanoparticle and create a detectable signal. This process is similar to the ELISA sandwich assay. The advantage of the gold nanoparticle over previous ELISA methods is its unique ability for low-level detection based on fluorescence. This effectively amplifies the detection of the protein or nucleic acid of interest by 6-7 orders of magnitude over previous methods.
Products
Verigene TM- This system screens for nucleic acids and proteins by integrating sample prep and fluid-processing for fully multiplexed assays. The nanotechnology harnessed in this system helps provide extremely accurate results for a wide range of assays in blood, cultures, or other media.
News
12.11.2006- Nanosphere is awarded a patent for the imaging of nanoprobes essential to the Verigene TM device
5.16.2006- Nanosphere closes a $57M round of series D financing led by Bain Capital
12.15.2005- Nanosphere is awaded a patent for their Biobarcode system of protein and nucleic acid detection
5.16.2002- Nanosphere named to Red Herring's 100 list
Collaborations
2.13.2006- Applied Neurosolutions and Nanosphere sign research agreement for the development of diagnostic tests for Alzheimer's disease
10.3.2002- Nanosphere enters into a contract with the U.S. Government Technical Support Working Group for a detection system of biological warfare agents
6.22.2002- TakaraBio Inc. and Nanosphere sign an intent for a development and distribution alliance
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